Acid Reflux Medication: What Works, What to Avoid, and How to Choose

When you feel that burning sensation rising from your stomach into your chest, you’re dealing with acid reflux medication, drugs designed to reduce stomach acid and ease the discomfort of gastroesophageal reflux disease (GERD). Also known as heartburn medicine, these treatments don’t just mask symptoms—they help your esophagus heal by lowering acid levels. But not all acid reflux medication is the same. Some work fast but wear off quick. Others take days to kick in but keep things quiet for longer. Knowing the difference matters—especially if you’ve been relying on them for weeks or months.

There are three main types you’ll run into. First, antacids, quick-acting chewables or liquids that neutralize acid on the spot. Also known as heartburn relievers, they’re great for sudden flare-ups but won’t stop the root cause. Then come H2 blockers, medications like famotidine and ranitidine that cut acid production for several hours. They’re stronger than antacids and often used before meals to prevent symptoms. And finally, proton pump inhibitors, the most powerful option, including omeprazole and esomeprazole, which shut down acid production at the source. Also known as PPIs, they’re the go-to for chronic GERD—but they’re not meant to be taken forever without a plan. Long-term use of PPIs can lead to nutrient deficiencies, bone issues, and even rebound acid reflux when you stop. That’s why knowing when to use each type is just as important as knowing how they work.

What you’ll find below is a collection of real, practical guides that cut through the noise. You’ll see how some meds interact with other drugs, what side effects actually matter, and which ones are worth switching from if you’re not getting relief. There’s no marketing fluff—just straight talk on what works, what doesn’t, and how to avoid common traps people fall into when managing acid reflux day after day. Whether you’re trying to get off PPIs safely or just want to know why your antacid isn’t doing enough, the posts here give you the tools to make smarter calls.